
Professor Utonium and his son Ken are studying the strange Chemical X. When a mochi cake falls into the formula, it changes into Chemical Z. Ken fires a ray of Chemical Z at a glacier in Tokyo Bay, however that causes strange lights to scatter, some of them aim at three normal girls, Momoko, Miyako, and Kaoru. This gives them the power to transform into superheroes, the Powerpuff Girls Z!

The Powerpuff Girls fight Mojo Jojo after he kidnaps kindergarten students in a cage and steal their candy.

Professor Utonium, his son Ken, Blossom, the Mayor, and Ms. Bellum and Poochi find Bubbles jumping cheerfully as she is attacked by Mojo Jojo and takes them in for research.

Buttercup reluctantly joins the group. The girls are put into the same class to make them get along and they stop Mojo from hogging all the food in a restaurant.

The girls take turns being a mother figure to Ken, while Mojo plans to turn everyone into monkeys

Climbing the Walls: Professor Utonium, Mr. Mayor, Ms. Bellum and the girls inspect the tall building which will become Mayor's Tower when Mojo tries to claim it to.

Fuzzy Lumpkins: Fuzzy Lumpkins keeps driving the girls and friends away while they try to enjoy a trip to the woods. Princess Morbucks: Classmate Princess Morbucks (Himeko) is hit by the black Z-Rays and plots to outshine the Powerpuff Girls.

Blossom is given the task of being the bodyguard of her favorite TV hero, Johnny Cosmo when Mojo threatens him. The Amoeba Boys (now including a lady) attempt to become villains with little success.

A local shop owner and the Girl's friend, Annie is hit by black Z-rays turning her into the monster Sedusa! She attempts to glamour herself to win the heart of her friend Jason.

Buttercup trains a young kid named Justin to become a better soccer player. After falling in love with Ms. Bellum, Fuzzy decides to take her back to the woods.

The arrogant hairdresser Gilbert is hit by black Z-Rays and uses his power to hypnotize the customers to accept his eccentric hairstyle.
Available on: TV Tokyo, AT-X