
Joey has struck out on his own and moved to Hollywood, hoping to truly make it as an actor. Joey says goodbye to a time when his friends were his family and welcomes the chance to turn his family into his friends. After reuniting with his high-strung sister Gina, a strong and sexy hairdresser, Joey moves in with her genius 20-year-old son, graduate student Michael, who literally is a rocket scientist. What Joey lacks in book smarts, however, he more than makes up for with his people skills, making him the best new friend his nephew could ask for.

Joey arrives in L.A. after his new agent offers him his choice of parts on two TV shows, and befriends his neighbor, Alex. His nephew, Michael, wants to move in with him at his new apartment, but Joey fears that this will upset his sister, Gina.

Gina is having trouble letting Michael live his own life, by constantly hanging out at Joey's place. Meanwhile, Joey is irritated by the notes his super leaves him. Also, the three of them go out to a bar where Joey and Gina try to teach Michael how to pick up women.

Having trouble meeting new people in L.A., Joey throws a party to get to know some of his neighbors. Unfortunately, the one he'd like to get to know, Jake, seems to be more interested in Gina. Also, Alex pretends to be Michael's girlfriend so that he can one-up his friend.

Joey joins Michael's book club to meet pretty women. Unfortunately for Michael, the girl he is crazy about, seems to have more interest in Joey than him. Meanwhile, looking to get her hairdressing work noticed, Gina bargains with Alex.

There's a vacant apartment in the complex, and Joey and Michael try to hide it from Gina, fearing that she'll want to move in to be closer to them. Also, Joey is understudying in three plays at once and unfortunately for him, he gets called upon to perform on stage in all three of them on the same evening.

Michael is sick and Gina is delighted cause now she feels needed again and takes care of him. However, this bothers Joey, because now his sister is around all the time, so Gina offers him to crash at her place until Michael gets better. While staying at Gina's, Joey meets her secret boyfriend and confronts him. Also, an actor named Brian Michael David Scott repeatedly tricks Joey into missing auditions.

After Gina keeps complaining about her current workplace, Joey decides to loan her some money, so that she can open her own salon, but she has second thoughts. Also, Alex's husband Eric returns to town and things get weird between him and Joey.

Gina's high school friend Donna comes to town, recently separated from her husband. Joey, who has had a huge crush on Donna for years, is happier than ever when they start going out. However, Donna confides in Gina that her husband wants to reconcile, and begs her not to tell Joey. Meanwhile, Michael is startled to discover that he was a great baseball player when he was younger.

Gina reveals to Joey that Donna is considering getting back together with her husband Ron, however, Joey decides that he won't give up without a fight. He plans a romantic week together with Donna in order to win her over. Unfortunately for him, just as he's about to leave to pick up Donna for their trip, Ron shows up at his place and confronts him. Thankfully, Gina and Michael manage to keep Ron busy which lets Joey slip away. Meanwhile, Alex discovers that she's hot and that hot girls get free stuff.

A discouraged Joey is just looking for an audition for a good show. At Alex's Northwestern alumni party, he's mistaken for a fellow alumni, and introduced to the Northwestern Mafia. They help him get an audition for a show called Deep Powder, described as "Baywatch on skis." Joey's a little depressed that he's auditioning for the father of 2 teenage characters.
Created by: Shana Goldberg-Meehan, Scott Silveri
Available on: NBC