
Masane Amaha and her daughter Rihoko are on the run from a government child welfare agency that wants to take Rihoko away from her mother. They are caught and Rihoko is taken away. Meanwhile, Masane is attacked by an advanced weapon that can disguise itself as a human being. When faced with the danger, a strange light emits from her wrist and she transforms into a powerful being. She becomes involved in a power struggle between powerful organizations, with her at the center of their attention because she holds the greatest power of them all, the legendary Witchblade.

Masane Amaha returns to Tokyo with her daughter, Rihoko, in order to start a new life. Unfortunatelly, a fight between her and some NSWF organisation members who want to separate her from her daughter, Masane is arrested.

After managing to awake the powers of the Witchblade, Masane is captured again and used as a test subject. Meanwhile, Rihoko starts searching for her mother.

Takayama offers Masane a job, but the only thing on Masane's mind is finding her daughter.

The appearance of the Witchblade draws the attention of Furumizu, the leader of the NSWF organisation. Meanwhile, Masane and her daughter start looking for a place to live.

Tozawa tries to investigate Masane, in order to find out the truth about the Witchblade. Masane refuses to talk, and is challanged to a fight by Shiori, one of the Cloneblades.

Masane is badly injured after her fight with Shiori and is rescued and taken care of by some of Dohji's men. Tozawa has witnessed the fight and decides to find out everything about the Witchblade.

Masane discovers more about Takayama's past. Meanwhile, Shiori goes berserk from over-using the Cloneblade, and decides to attack Masame one more time.

Masane is forced to use the Witchblade in front of Tozawa, when they are attacked by an ex-con.

Masane and Tozawa learn more about the ex-con's past.

Masane is forced to accompany Takayama to a party, where she must confront Wado, one of Takayama's rivals.
Available on: ANIMAX, TBS