
The series revolves around the friendship of four African-American women in different phases of their lives. They explore the many trials and tribulations that most women face today such as relationships, family, friends and other current issues that will interest most women. Whether it’s getting over a divorce, finding a career, or looking for true love, Girlfriends delivers along with comedy and wit.

Joan Clayton, a successful attorney, prepares to celebrate her 29th birthday (although she claims to be 26 to make her achievements seem more impressive). Toni, Joan's best friend, begins dating Charles, a venture capitalist with a propensity for toe-sucking who dated Joan until he freaked out at the prospect of marriage. Toni tries to hide the truth, but their friend Lynn forces her to confess to Joan. Joan claims she has no problem with Toni bringing Charles to her birthday party; but then brings her friend and colleague, William, to try to make him jealous. Joan is furious to learn that Charles is now interested in settling down, and the evening comes to a screeching halt. Meanwhile, Toni constantly clashes with Maya, Joan's sassy assistant.

After Joan reveals that she hasn't had sex in a year, her friends push her to go for a one-night stand. Joan is reluctant because she generally doesn't sleep with anyone until she has been in a relationship for three months, but tries to make a move on Davis Hamilton, a handsome man who owns the restaurant the girls frequent. She convinces Davis to drive her home and makes a pass at him, only to learn that he is engaged. Although nothing happens between them, Joan tells Toni and Lynn that she slept with him. When the girls blab the news around town, Davis' fiancée dumps him, leaving Joan to struggle for a way to clean up the mess.

Toni and Maya get into another argument before an evening out, in part because Toni refuses to believe that Maya can get the girls into an exclusive club. Toni tries to gain admission to the club and fails. Maya shows up and easily gets herself, Joan, Lynn and William past the doorman. Joan convinces the reluctant Maya to also get Toni into the club. When the doorman waves to Toni, another woman believes the wave was meant for her, and they get into an argument. Joan tries to play peacemaker, but the situation turns into a brawl. Maya and Lynn jump into the fight, but Toni is hurt by the fact that Joan fails to back her up. She begins to question their friendship, so Joan searches for a way to patch things up.

Joan, Toni and Lynn set up dates with men they met over the Internet. Lynn's guy never shows up (his parole was denied), while Toni rejects hers because his skin is too dark. Although conspiracy theorist Maya warns that he will turn out to be a serial killer, Joan is pleased with her date, Marcus. Joan freaks out after discovering that Marcus wears a girdle because he has large hips, prompting Toni (who had taken heat from the girls over her treatment of her date) to take her to task for her behavior. Meanwhile, William also uses the Internet in an attempt to find love. He finally gets a date, but the woman seems to be completely crazy.

Joan grows tired of the clingy Marcus and plans to break up with him, but only winds up complicating the situation by having ""pity sex"" with him. The girls try to help her out by bombarding Marcus with negative facts about Joan in the hopes that he will dump her. Meanwhile, Maya gets involved in a get-rich-quick scheme.

Joan plans an elaborate scheme to get revenge on William for the latest in a series of Halloween pranks. Toni is put off when her date asks her to engage in a threesome--with a stuffed animal.

Joan sees Maya's husband, Darnell, in a possibly compromising situation with another woman. Her gut tells her that something may be going on, but she agonizes over whether to share this information with Maya. Meanwhile, Toni begins dating a white city councilman who is also running for mayor. He becomes fascinated with her hair after she reveals that she wears a weave.

Joan turns to her friends for support when she fears that she might be pregnant. When a test turns out positive, she tries to cope with her fears about impending motherhood. Meanwhile, Lynn recalls memories of her ""white"" childhood after receiving a box of belongings from her mother.

Joan finds herself alone on Thanksgiving after everyone makes other plans for the holiday. After dining at 847, she meets Davis's friend Preston Hall, a handsome and highly successful attorney. Joan invites him back to her place for a home-cooked meal before he has to leave on the red-eye, but her friends suddenly begin appearing and she can't seem to get them to leave.

Maya and Darnell plan to renew their wedding vows, and Joan agrees to hold the event at her house. However, Joan constantly disagrees with Maya's choices and tries to mold the event into her own dream wedding. Maya tells Joan that she no longer wants her to be a bridesmaid, and later rebuffs her apology and takes her to task for constantly looking down on Maya. Meanwhile, Toni grows concerned by the tendency for black men to marry outside of their race. She determines that she and Lynn must do what they can to bring William ""back to the fold.""
Created by: Mara Brock Akil
Available on: UPN, The CW