
Ginko, a Mushi master, travels from place to place researching the Mushi and helping people who are suffering because of it.

Shinra, a boy living in a forest with mysterious powers, calls for Ginko, The Mushishi, to help him with his problems. While Ginko is staying with Shinra, he tells him all about Mushi and his powers. Later on, while walking in Shinra's house at night, Ginko finds a Mushi... But this isn't an ordinary Mushi, it's Shinra's grandmother!

A girl named Sui has an unusual disease that causes pain in her eyes whenever she sees light. She has to be locked in a pitch black shed that has no light in it. A boy named Biki helps Sui by removing bandages, giving her food, and just talking to her. Biki's mother is worried about him getting the illness, so she tells him not to stay as long as he normally would with Sui. One day while Biki is talking to her, she tells him why she has that illness: There are Mushi in her eyes. Biki continues to take care of her until one night when he is reading by a candle, a strange pain comes to his eyes.

On silent snowy nights, when no sounds can be heard, many people go deaf in one or both ears. The doctors can't do anything, so they think it might be paranormal. Ginko looks into some of the villager's ears and he tells them that the cause is a Mushi called "Un". After dealing with their small problems there is one more person who has lost sound in both of his ears and his condition is very different than the other people's, as he has also grown four horns on his head.

Ginko hears a rumor around town that a man is has prophetic dreams every once in a while. He suspects that Mushi are living in his dreams. He gives the man medicine to keep them under control and says he will come back when he has used about all of them. When Ginko returns, the village is deserted and torn up. Ginko finds the man alone in is house. The man then tells him about what happened while he was away.

Adashino-sensei is looking to buy some of the items that Ginko has obtained on his journey. He especially wants the wine cup that was drawn by Shinra, But Ginko says it's too rare to be sold to collectors. He tells Adoshenei-sensei about the strange being he met while in the forest and he also explains how the swamp is moving towards the sea. This looks like the work of a Mushi...

Ginko is on another adventure as he is brought to a very peculiar island, by a young boy Nagi. Ginko is taken to see a girl, who the island inhabitants refer to as "Ikigami" and is said to be able to perform miracles however Ginko discovers that there is more to this.

On a rainy day Ginko takes a rest from his travels and comes across a man named Kourou who seems to be obsessed with a rainbow. To pass the time Kourou reminisces in his past, with the events which led to him pursuing rainbows whenever they appear. Ginko explains to him that the rainbow which he is searching for is actually a Mushi known as "Koda" but there seems to be more to it.

Ginko is waiting along the sea shore, for a transport to get him across the bay when he meets a man called Shirou, who lost his wife under strange circumstances. Ginko seems interested and decides to listen to his story about how he lost his wife in a swarm of sea snakes, during fog. Ginko later comes back with information on the Mushi that caused the bizarre events.

While on his journey, Ginko stumbles upon a town which has yielded a great crop this year, thanks to their ancestors. However, it is said that someone must be sacrificed in exchange. Ginko finds this peculiar and decides to investigate further, by going to see the village "Saishu-sama" (chief mourner) who may have something to do with it.

Some kids enter Adashino-sensei's shed and find a lot of strange things, but there's one thing in particular that interests them. It's night and Adashino-sensei is called upon to look at one of the kids, a girl who has become bitterly cold, and the cause is a mysterious ink stone she touched. Luckily for Adashino-sensei, Ginko is passing through the village, and he shows him the ink stone, which he identifies it as a "Kumohami."
Available on: Fuji TV, Gunma TV, Tokyo MX, BS11, Tochigi TV