
Senbei Norimaki, known by his nickname Dr. Slump, a genius yet under-respected inventor and roboticist, creates an android by the name of Arale, and poses her as his little sister. What starts as an experiment in robotics turns into an adventure every day for the residents of Penguin Village, a wacky rural community with several colorful characters interacting with Arale and her creator.
Senbei creates Arale and takes her on a test-run as a convincing little sister. However, she's not as tuned-up as her creator would have expected. / Arale is enrolled in school, and tries to win over the "tough kids" Akane, Taro, and his little brother Peasuke. Meanwhile, Senbei gets a crush on his creation's homeroom teacher, Midori Yamabuki.
Arale's superhuman strength gets word around the school, and all the clubs want her to join them. / Arale comes home to tell Senbei that an integral body part is missing on her body, to which the doctor invents x-ray specs for definitely-not-perverted research purposes.
Senbei tests out his newest invention: an alarm clock-shaped time machine called the Time Slipper. On its inaugural voyage, Arale gets lost in ancient Japan. / Arale and friends use the Time Slipper to go back to the days of the dinosaurs, and find a mysterious egg.
The babylike creature that hatched from the prehistoric egg, Gatchan, is the subject of several discoveries for Arale and Senbei. / A day in the life of Gatchan, as they go about town interacting with the Penguin Village citizens.
Arale rescues a bear, but trouble is afoot when her new friend is to be released back into the wild. / Senbei creates a raygun that can make things bigger or smaller than their intended size. Naturally, Arale causes some mischief with it.
Arale tells Senbei that her teacher is coming for a home visit. Knowing he has to look his best for Miss Yamabuki, he creates a barber robot to spiff him up. / Criminal Joe Dunn holds Arale and Gatchan hostage, but doesn't realize that he's underpowered compared to the two little terrors he's kidnapped.
A day in the life of Arale, from her police car destructions to her school life, and home again after accidentally eating whiskey bonbons.
The tricky fox Donbe uses his kitsune powers of transformation to pull pranks on the town. When he runs into trouble, Arale and Senbei must put their differences aside with the critter who caused them too much trouble in one day.
Arale reveals to Senbei that Miss Yamabuki wears strawberry-patterned panties. In a fit of pure horniness, he enlists the help of the animals of Penguin Village to get him a peek.
The alien King Nikochan and his assistant abduct Arale and Gatchan, with the expressed intent to destroy the world. However, Gatchan's appetite for metal causes their ship to crash, which leaves the two invaders seeking help from the earth people.
Available on: Fuji TV, Tokai Television Broadcasting, Kansai TV, Fukui TV, Hokkaido Cultural Broadcasting, Sendai Television, SAGA TV, Ishikawa TV, TNC, OHK, Television Shin Hiroshima System, TV Shizuoka, UMK TV Miyazaki, NBS, TSK, Ehime Broadcasting, Yamagata Television System, AKT, Toyama Television